Startup City

Uncaged
Engineering Biomaterials for Scalable Performance and Adoption

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Stephanie Downs, Uncaged | Startup City | Best Biomaterials CompanyStephanie Downs, CEO
Brands across industries are under increasing pressure to replace traditional animal and petroleum-based materials with alternatives that meet both environmental and performance expectations. However, many biomaterials struggle to balance durability, manufacturability and scalability, making adoption difficult for companies operating at an industrial scale.

Uncaged addresses this challenge by focusing on molecular-level material design that aligns with both performance requirements and manufacturing realities. Its flagship material, ELEVATE, is engineered using grain proteins to replicate the structural properties of collagen.

“ELEVATE uses grain proteins, fused with other plant-based elements, to replicate the scaffolding functions of collagen,” says Stephanie Downs, CEO.

Bridging Performance and Manufacturability

A key barrier to biomaterial adoption is the difficulty of integrating new materials into existing production systems. Manufacturers are often hesitant to disrupt established processes, especially when production volumes are high and consistency is critical.

Uncaged addresses this by designing materials that can be incorporated into existing manufacturing workflows without requiring specialized training or equipment. This reduces friction during adoption and enables brands to test and scale new materials more efficiently.

The company also focused early on solving challenges related to consistency in production. By working closely with industrial partners, it refined its roll-to-roll processes to achieve reliable output at scale. Today, the material can be produced in thousands of meters per week with consistent quality, marking a transition from experimental development to commercial readiness.

This scalability ensures that brands are not limited to pilot programs but can integrate the material into full production cycles, supporting broader adoption across multiple product categories and use cases.

Engineering Materials at the Molecular Level

Uncaged’s approach is rooted in a detailed analysis of collagen structures to replicate the performance characteristics of traditional leather. Its BioFuze technology creates fibral networks by combining grain-derived proteins with other bio-based elements, enabling materials that mimic the strength and flexibility of animal hides.

This structure allows the material to be engineered for different applications. Thinner constructions can support fashion use cases, while thicker configurations are designed for durability in automotive and mobility environments.

  • ELEVATE uses grain proteins, fused with other plant-based elements, to replicate the scaffolding functions of collagen.


The development process required extensive experimentation to achieve the desired balance of softness, strength and biodegradability. By replacing both animal collagen and plastic components, the company created a material that maintains performance while remaining fully bio-based.

The ability to customize color and scent using natural pigments and botanical extracts further expands its application potential, allowing brands to differentiate their products while maintaining material consistency.

Advancing Toward Measurable Impact

Uncaged’s progress is demonstrated through the evolution of its material from early prototypes to a commercially viable product. Initial versions met environmental goals but required refinement to satisfy durability and aesthetic standards expected by premium brands.

Through iterative development and feedback from early customers, the company improved both performance and consistency. The resulting material delivers measurable environmental benefits, including significant reductions in water usage, energy consumption and greenhouse gas emissions compared to traditional leather production.

Looking ahead, increasing demand for transparency and verifiable sustainability metrics is expected to shape material selection across industries. Brands are focusing not only on whether materials are sustainable, but also on how their impact is measured and validated.

Uncaged is positioning itself within this shift by emphasizing both performance and traceability. Its approach aligns material development with evolving regulatory and consumer expectations, supporting broader adoption across sectors such as fashion and automotive.

By combining scalable manufacturing with measurable environmental performance, Uncaged is contributing to a transition where biomaterials move from niche solutions to widely adopted materials across industries.

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Best Biomaterials Company 2026

Company
Uncaged

Management
Stephanie Downs, CEO

Description
Uncaged develops biomaterials designed as alternatives to traditional leather. Its ELEVATE material uses grain-based proteins and bio-based elements to replicate collagen structure, enabling scalable, biodegradable solutions for industries including fashion, automotive and consumer products.